The English code-breaking game known as Bulls and Cows, popularized as the board game Mastermind, has been adapted for applications in fields such as mathematics, computing, and psychology. Mastermind has been proposed as a tool for teaching logic in mathematics courses, but the problem-solving skills emphasized by the game are also relevant to the life sciences. We propose that the game can be used to teach specific lessons and spark discussions about scientific reasoning, covering topics such as sound experimental design, hypothesis-testing, careful interpretation of results, and the effective use of controls."
Using the Game of Mastermind to Teach, Practice, and Discuss Scientific Reasoning Skills. (2011) PLoS Biol 9(1): e1000578. doi:10.1371/journal.pbio.1000578